A new study indicate broad differences in the gene activity of humans and chimpanzees, affecting nearly 1000 genes, even though humans and chimps share 97% of genes. Transcription factors are proteins that bind to specific regions of DNA to promote or repress the activity of many genes. A single transcription factor can spur the transcription of dozens of genes into messenger RNA. A small change in transcription factor expression can produce a large effect on overall gene expression differences between chimps and humans.
Reference: Science Daily